References

A1 - RSI Drugs / Airway Equipment Sizes

1. “Pharmacology and Techniques of Airway Management” and “Pediatric Airway Management” In: Walls RM, editor. Manual of Emergency Airway Management. 4th ed. Philadelphia: Wolters Kluwer; 2012.  

2. Ahn J, Bryant A. Focus On: Rapid Sequence Intubation Pharmacology. ACEP Now, September 2010.

3. Caro D. Induction agents for rapid sequence intubation in adults. In: UpToDate, Post TW (Ed), UpToDate, 2016. Accessed on Dec 4, 2016. 

4. Weingart, S. Podcast 92 – EMCrit Intubation Checklist. EMCrit Blog. Published on February 5, 2013. Accessed on Dec 4, 2016. 

5. American Heart Association. PALS Reference Card. Pediatric Advanced Life Support Provider Manual. Dallas, TX: American Heart Association; 2011. 

6. Broselow Pediatric Emergency Tape. Distributed by Armstrong Medical Industries, Lincolnshire, IL.

A2 - Adult Airway Management Pause / Airway Assessment

Adult Airway Management Pause copyright information:

1. Huffman J, Laerz T, Wylie B, East C. Adult Airway Management Pause, Version 10.1, Sept 2018. AHS Calgary Zone. Used with permission. Contact: james.huffman@ahs.ca or tona.laerz@ahs.ca or christine.east@ahs.ca for more information.

2. Gaudet J, Haber J, Lord J. Difficult Airway Management Workshop Participant Manual. December 2016. University of Calgary/AHS. 

3. Scott Weingart. The HOP Mnemonic. EMCrit Blog. June 21, 2012. 

4. 3-3-2 Rule Illustration. C.East, alteration of original illustration by Vassia Atanassova (Spiritia), via Wikimedia Commons

5. Mallampati Scoring Illustration. By Jmarchn - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=12842847

B1 - Ventilator Settings

1. Weingart, Scott. Managing Initial Mechanical Ventilation in the Emergency Department. Annals of Emergency Medicine. 2016 Nov;68(5):614–617. (See also this commentary that is critical of some aspects of Scott Weingart’s approach to the vent: http://www.annemergmed.com/article/S0196-0644(16)31202-1/fulltext)

2. Wright BJ. Lung-protective Ventilation Strategies and Adjunctive Treatments for the Emergency Medicine Patient with Acute Respiratory Failure. Emerg Med Clin North Am. 2014 Nov;32(4):871-87.

3. Santanilla JI. Respiratory Procedures: Mechanical Ventilation. In: Hedges, J. and Roberts, J. (2014). Roberts and Hedges' clinical procedures in emergency medicine 6e. Philadelphia, PA: Elsevier Saunders.

4. Modes of Mechanical Ventilation. Open Anesthesia. Accessed Jul 11, 2017. 

5. Brenner, B. et al. Intubation and Mechanical Ventilation of the Asthmatic Patient in Respiratory Failure. Proc Am Thorac Soc 2009(6) 371–379.

6. Thomson C, Hasegawa K. Invasive mechanical ventilation in adults with acute exacerbations of asthma. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 11, 2017.

7. Morgenstern J. Post-intubation deterioration in asthma. First10EM Blog. Aug 24, 2015, accessed Dec 18, 2016. 

B2 - Status Asthmaticus in Adults / Intubation in Severe Adult Asthma / Non-Invasive Positive Pressure Ventilation in the ED

1. Kenyon N, Albertson T. Status Asthmaticus: From the ED to the ICU. Clin Rev Allerg Immu 2001(20). 271-92.

2. Swadron S, Herbert M. C3 Asthma Podcast. EM:RAP. Aug 1, 2016. Available by subscription.

3. Morgenstern J. Post-intubation deterioration in asthma. First10EM Blog. Aug 24, 2015, accessed Dec 18, 2016. 

4. Goodacre S et al. The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma. Health Technol Assess. 2014 Apr;18(22):1-168

5. Rezaie S. The Crashing Asthmatic. RebelEM Blog. Jun 1, 2015, accessed Dec 17, 2016. 

6. Weingart, S, Orman R. “Intubated Asthmatic” in EM:RAP June 2016 Podcast. EM:RAP. Jun 1, 2016.

7. Brenner, B. et al. Intubation and Mechanical Ventilation of the Asthmatic Patient in Respiratory Failure. Proc Am Thorac Soc 2009(6) 371–379.

8. Strong Medicine. Non-Invasive Positive Pressure Ventilation (Mechanical Ventilation - Lecture 6) [Youtube]. Nov 21, 2011. Retrieved Jul 18, 2017. 

9. Ahn J, Pillow T. Focus On: Noninvasive Positive Pressure Ventilation In the Emergency Department. ACEP Now, March 2010.

10. Broderick KB, DeBlieux PM. “Noninvasive Mechanical Ventilation” in: Walls R, Murphy MF, editors. Manual of Emergency Airway Management. 4th ed, 2012.

11. Nickson C. Noninvasive Ventilation (NIV). Life in the Fast Lane Blog. Dec 21 2015. Accessed Jul 18 2017. 

C1 - Pressor and Inotrope Infusions / Push Dose Pressors, Dirty Epi Drip and Peds Epi Spritzer

1. Barry, Arden. Vasopressors and Inotropes - Quick Reference Guide, Version 1.4 (June 2013). Resource developed at Mazankowski Alberta Heart Institute for CCU residents.

2. Coralic, Zlatan. The Dirty Epi Drip: IV Epinephrine When You Need It. ALiEM Blog. Published June 27, 2013. Accessed Nov 26, 2016. 

3. Djogovic et al. Vasopressor and Inotrope Use in Canadian Emergency Departments: Evidence Based Consensus Guidelines. CAEP Position Statement. CJEM 2015;17(S1):1–16

4. Senz A, Nunnink L. Review article: inotrope and vasopressor use in the emergency department. Emerg Med Australas. 2009 Oct;21(5):342-51.

5. Waechter, Jason. Hypotension, mechanisms, treatment and red flags. Presentation for ICU residents. Created 2012, revised 2013.

6. Weingart, Scott. EMCrit Podcast 6 – Push-Dose Pressors. EMCrit Blog. Published Jul 10, 2009. Accessed Nov 26, 2016.

7. Epi Spritzer instructions; From discussion with pediatric emergency physicians at Alberta Children’s Hospital

C2 - Selected Cardioactive Drugs / Approach to BP Lowering in Hypertensive Emergencies

1. Prutkin JM. Overview of the acute management of tachyarrhythmias. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 11, 2017.

2. Cooper, B. Amiodarone vs Procainamide for Stable VT. EM Docs Blog. Published Aug 11, 2014. Accessed Jul 11, 2017.

3. Heller, Adrian. Tachydysrhythmia Notes (handout from 2016 rounds). August 2016. Available on CalgaryEM website under Documents.

4. Varon J and Elliot WJ. Management of severe asymptomatic hypertension (hypertensive urgencies) in adults. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jun 19, 2018.

5. Casaubon LK, Boulanger JM, Blacquiere D, et al; Heart and Stroke Foundation of Canada Canadian Stroke Best Practices Advisory Committee. Canadian Stroke Best Practice Recommendations: Hyperacute Stroke Care Guidelines, Update 2015. Int J Stroke. 2015 Aug;10(6):924-40

6. 2017 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2018;71:e127-e248.

7. Black JH and Manning WJ. Management of Acute Aortic Dissection. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jun 19, 2018.

8. Magee LA et al. Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy. SOGC Clinical Practice Guideline. J Obstet Gynaecol Can 2014;36(5):416–438

C3 - Bleeding and Coagulopathy / Thrombolysis in the ED

1. Calgary Lab Services. RGH Massive Transfusion Protocol. Mar 16, 2015. Available on Insite.

2. Kutcher ME, Cohen MJ. Acute coagulopathy associated with trauma. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 20, 2017.

3. Hull RD, Garcia DA. Management of warfarin-associated bleeding or supratherapeutic INR. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 11, 2017.

4. Garcia DA, Crowther M. Management of bleeding in patients receiving direct oral anticoagulants. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 11, 2017.

5. Alberta Health Services. Direct Oral Anticoagulant Agents. Provincial Guideline HCS-115-01. Mar 10, 2017. Available on Insite.

6. Leung LL. Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 11, 2017.

7. Shah NL and Intagliata N. Hemostatic abnormalities in patients with liver disease. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 11, 2017.

8. Rick ME. Treatment of von Willebrand disease. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 11, 2017.

9. Hoots WK, Shapiro AD. Treatment of bleeding and perioperative management in hemophilia A and B. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 11, 2017.

10. Silvergleid AJ. Clinical use of Cryoprecipitate. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 11, 2017. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jun 19, 2018.

11. Rivera-Bou WL. Thrombolytic Therapy. In: Medscape Schraga ED (Ed), Updated: Dec 31, 2017 Accessed Jun 19, 2018.

12. Tapson VF and Weinburg AS. Thrombolytic (fibrinolytic) therapy in acute pulmonary embolism and lower extremity deep vein thrombosis. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jun 19, 2018.

13. Chatterjee S et al. Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis. JAMA. 2014 Jun 18;311(23):2414-21. PMID: 24938564.

14. American Heart Association. 2015 Guidelines Guidelines for CPR & Emergency Cardiovascular Care, with 2018 Focused Updates. Web-Based Integrated Guidelines, adapted from Circulation. 2015;132:S368–S382, originally published November 3, 2015, accessed November 18, 2018. Available at https://eccguidelines.heart.org/index.php/circulation/cpr-ecc-guidelines-2/.

15. Gibson CM and Levin T. Characteristics of fibrinolytic (thrombolytic) agents and clinical trials in acute ST elevation myocardial infarction. 

16. Casaubon LK, Boulanger JM, Blacquiere D, et al; Heart and Stroke Foundation of Canada Canadian Stroke Best Practices Advisory Committee. Canadian Stroke Best Practice Recommendations: Hyperacute Stroke Care Guidelines, Update 2015. Int J Stroke. 2015 Aug;10(6):924-40

17. Menon BK, Buck BH, Singh N, Deschaintre Y, Almekhlafi MA, Coutts SB, et al. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (act): A Pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial. The Lancet. 2022Jun29;400(10347):161–9.  

C3 - Selected Adult Cardiac Arrest Drugs / An Approach to Cardiac Arrest / EKG-Based Approach to PEA

1. 2015 American Heart Association Guidelines for CPR & Emergency Cardiovascular Care. Part 7: Adult Advanced Cardiovascular Life Support. Circulation 2015;132(18)S2. Accessible online as web-based integrated guidelines.

2. Weisberg LS. Management of severe hyperkalemia. Crit Care Med. 2008 Dec;36(12):3246-51.

3. Tapson VF. Fibrinolytic (thrombolytic) therapy in acute pulmonary embolism and lower extremity deep vein thrombosis. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Nov 17, 2017.

4. 2015 American Heart Association Guidelines for CPR & Emergency Cardiovascular Care. Part 3: Ethical Issues. Circulation 2015;132(18)S2. Accessible online as web-based integrated guidelines.

5. Jabre P et al. Early Identification of Patients With Out-of-Hospital Cardiac Arrest With No Chance of Survival and Consideration for Organ Donation. Ann Intern Med. 2016;165(11):770. Epub 2016 Sep 13.

6. Podrid P. Prognosis and outcomes following sudden cardiac arrest in adults. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Nov 17, 2017.

7. Blyth L et al. Bedside Focused Echocardiography as Predictor of Survival in Cardiac Arrest Patients: A Systematic Review. Acad Emerg Med, 19(10) 1119–1218, e48–e49.

8. Tsou PY et al. Accuracy of point-of-care focused echocardiography in predicting outcome of resuscitation in cardiac arrest patients: A systematic review and meta-analysis. Resuscitation 114 (2017) 92–99.

9. Meaney PA et al. CPR Quality: Improving Cardiac Resuscitation Outcomes Both Inside and Outside the Hospital: A Consensus Statement From the American Heart Association. Circulation 2013;128(4).

10. Littmann et al. A Simplified And Structured Teaching Tool for the Evaluation and Management of Pulseless Electrical Activity. Med Princ Pract 2014;23:1-6.

D1 - Seizures in Adults and Children < 1 mos / Seizures in Neonates < 1 mos

1. Morgenstern J. Management of status epilepticus in the emergency department. First10EM Blog. Nov 16, 2015, accessed July 5, 2017.

2. ACH Seizure Algorithms for Neonates and Children. Apr 25, 2011. Available on AHS Insite> ACH ED Clinical Protocols and Pathways.

D2 - Severe Traumatic Brain Injury Management / GCS Adult / Dermatomes and Myotomes

1. Carney N et al. Guidelines for the Management of Severe Traumatic Brain Injury, 4E. Brain Trauma Foundation TBI Guidelines. Neurosurg. 2016 Sep 20. S1;1-10.

2. Zammit C, Knight W. Severe Traumatic Brain Injury in Adults. Emergency Medicine Practice, EB Medicine. 2013(15)3. Available by subscription.

3. Adapted from: Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974;2(7872):81-4. 

4. Adapted from: American Spinal Injury Association International Standards for Neurological Classification of Spinal Cord Injury

5. Dermatomes illustration: Ralf Stephan altered via Wikimedia Commons (https://commons.wikimedia.org/wiki/File:Dermatoms_alt.svg)

D3 - Selected Emergency Toxicology Treatments

1. Heard K and Dart R. Acetaminophen (paracetamol) poisoning in adults: Treatment. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 22, 2017.

2. Hendrickson RG and Kusin S. Gastrointestinal decontamination of the poisoned patient. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 22, 2017.

3. Bird S. Organophosphate and carbamate poisoning. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 22, 2017.

4. Barrueto F. Beta blocker poisoning. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 22, 2017.

5. Barrueto F. Calcium channel blocker poisoning. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 22, 2017.

6. Nelson L and Odujebe O. Cocaine: Acute intoxication. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 22, 2017.

7. Hoffman RS and Weinhouse GL. Management of moderate and severe alcohol withdrawal syndromes. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 22, 2017.

8. Salhanick S. Tricyclic antidepressant poisoning. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 22, 2017.

9. Boyer EW and Weibrecht KW. Salicylate (aspirin) poisoning in adults. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 22, 2017.

10. Liebelt EL. Acute iron poisoning. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 26, 2017.

11. Levine ML and O’Connor A. Digitalis (cardiac glycoside) poisoning. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 26, 2017.

12. Sivilotti ML and Burns MM. Methanol and ethylene glycol poisoning. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 26, 2017.

13. Desai S and Su M. Cyanide poisoning. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 26, 2017.

14. Warren L and Pak A. Local anesthetic systemic toxicity. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 26, 2017.

15. Prchal JT. Clinical features, diagnosis, and treatment of methemoglobinemia. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 26, 2017.

16. Stolbach A and Hoffman RS. Acute opioid intoxication in adults. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 26, 2017.

17. Rao R. Isoniazid (INH) poisoning. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed June 26, 2017.

18. Helman A, Lloyd T. Emergency Management of Opioid Misuse, Overdose and Withdrawal (Episode 116). Emergency Medicine Cases. https://emergencymedicinecases.com/opioid-misuse-overdose-withdrawal/. Accessed November 15, 2018.

O1 - Anaphylaxis in Adults / Anaphylaxis in Children

1. Campbell, R et al. Emergency department diagnosis and treatment of anaphylaxis: a practice parameter. Ann Allergy Asthma Immunol 113(2014)599-608

2. Cheng, A. Emergency treatment of anaphylaxis in infants and children. Canadian Paediatric Society Position Statement. Paediatr Child Health 2011;16(1):35-40.

O2 - Hyperkalemia in Adults / DKA in Adults

1. Weisberg LS. Management of severe hyperkalemia. Crit Care Med. 2008 Dec;36(12):3246-51.

2. Mount DB. Treatment and prevention of hyperkalemia in adults. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Jul 5, 2017.

3. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. CDA 2013 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Can J Diabetes 2013;37(suppl 1):S1-S212. 

4. Chiasson J-L et al. Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state. CMAJ. 2003 Apr 1;168(7):859–66.

5. Kitabchi A. et al. Management of hyperglycemic crises in patients with diabetes Diabetes Care 24;2001:1335-43

6. Cardoso L, Vicente N, Rodrigues D, Gomes L, Carrilho F. Controversies in the management of hyperglycaemic emergencies in adults with diabetes. Metabolism. 2017;68:43-54.

O3 - Selected Obstetrical Emergencies / Postpartum Hemorrhage and Selected Procedures

1. American College of Obstetricians and Gynecologists (ACOG) Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet Gynecol 2019; 133:e1-e25.

2. Magee LA et al. Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy. SOGC Clinical Practice Guideline. J Obstet Gynaecol Can 2014;36(5):416–438

3. Houry D, Keadey M. Complications In Pregnancy Part I: Early Pregnancy. Emergency Medicine Practice, EB Medicine. 2007(9)6. Available by subscription.

4. Moise KJ. Prevention of Rhesus (D) alloimmunization in pregnancy. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Aug 7, 2017.

5. Keadey M, Houry D. Complications In Pregnancy Part II: Hypertensive Disorders Of Pregnancy And Vaginal Bleeding. Emergency Medicine Practice, EB Medicine. 2009(11)5. Available by subscription. 

6. Belfort MA. Postpartum hemorrhage: Medical and minimally invasive management. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Aug 7, 2017.

7. Drugs and doses taken from AHS Calgary Zone “Post Partum Hemorrhage” order set on Sunrise Clinical Manager. Accessed Aug 7, 2017.

8. Zelop CM. Cardiopulmonary arrest in pregnancy. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Aug 7, 2017.

9. Rose CH et al. Challenging the 4- to 5-minute rule: from perimortem cesarean to resuscitative hysterotomy. AJOG 2015(213)5, 653–656, 653.e1.

10. Lew GH, Pulia MS. Emergency Childbirth: Perimortem Caesarean Section. In Hedges, J. and Roberts, J. (2014). Roberts and Hedges' clinical procedures in emergency medicine 6e. Philadelphia, PA: Elsevier Saunders.

11. Rodis JF. Shoulder dystocia: Intrapartum diagnosis, management, and outcome. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Aug 7, 2017.

O4 - Pediatric Vital Signs and GCS / Selected Paediatric Resuscitation Drugs

1. American Heart Association. Pediatric Advanced Life Support. Dallas, TX: American Heart Association; 2015.

2. The Hospital For Sick Children (SickKids). Nursing Student Orientation; Module 2: Clinical Care. Accessed Oct 9, 2017. 

3. Adapted from: Holmes JF, Palchak MJ, MacFarlane T, Kuppermann N. Performance of the Pediatric Glasgow Coma Scale in children with blunt head trauma. Acad Emerg Med 2005;12(9):814-9.

O5 - An Approach to Adult Procedural Sedation / Selected Paediatric Analgesic and Sedative Drugs

• 1. Herbert D and Seadon S. Procedural Sedation and Analgesia. 2016. Resource provided to University of Calgary CCFP-EM Residents.

  2. Alberta Health Services. Emergency Physician Procedural Sedation / Medication Administration Record. Form available in AHS Calgary Zone Emergency Departments.

  3. Frank RL. Procedural sedation in adults outside the operating room. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Nov 24, 2018.

  4. Alberta Health Services. Alberta Children's Hospital Procedural Sedation Medication Worksheet. Form available at ACH ED. 

  5. Pain Assessment And Management Initiative. Pain Management and Dosing Guide. October 2017. University of Florida Health Science Center/Jacksonville, Department of Emergency Medicine Division of Research. Accessed Nov 24, 2018. Available at http://pami.emergency.med.jax.ufl.edu/resources/dosing-guide/.

  6. Hsu DC and Cravero JP. Procedural sedation in children outside of the operating room. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. Accessed Nov 24, 2018.

  7. Kilian M, Helman A. Pediatric Procedural Sedation (Episode 76). Emergency Medicine Cases. https://emergencymedicinecases.com/pediatric-procedural-sedation/. Accessed December 14, 2018.

  8. Bhatt M et al. Risk Factors for Adverse Events in Emergency Department Procedural Sedation for Children. JAMA Pediatr. 2017 Oct 1;171(10):957-964. doi: 10.1001/jamapediatrics.2017.2135.